2-Chloromethyl-4-methoxy-pyridine → HCID 67592204, compound

Participants

Reaction Steps

By the method of Example 13, the title product of Example 20 (494 mg, 3 mmol) and freshly prepared 4-methoxy-2-picolyl chloride (903 mg, 3 mmol) were converted to present title product, purified by chromatography on silica gel using 51:25:4 toluene:ethyl acetate:isopropanol as eluant and recrystallization from toluene, 564 mg; m.p. 80°-82° C.; tlc Rf 0.3 (19:1 CH2Cl2 :isopropanol); exact mass calculated: 409.1531; found: 409.1530.

Provenance & Evidence