Sodium Hydroxide → HCID 19990237, compound

HRID 346075Notes

Reaction equation

HRID 346075 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[C:10]([N:16]2[CH2:20][CH2:19][O:18]C2=O)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>>[CH2:1]([N:8]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[C:10]([NH:16][CH2:20][CH2:19][OH:18])=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 19990235HCID 19990235, compound

Product 1

HCID 19990237HCID 19990237, compound

Procedure

1 00 g (0.35 mmoles) of N-(1-benzyl-4-nitropyrazolyl) oxazolidine-2-one is heated in 10 ml 5 normal sodium hydroxide solution for 4 hours at 70° C. The solvent is distilled off in the rotary evaporator in vacuum and the residue is separated by means of column chromatography using silica gel with a mixture of chloroform and methanol (10:1).

Workup

  1. distillationThe solvent is distilled off in the rotary evaporator in vacuum
  2. customthe residue is separated by means of column chromatography
  3. additionwith a mixture of chloroform and methanol (10:1)

Sources & evidence

ORD record
ord-ed6e3e91a2ec409b91141b97902ef3ba
Source dataset
uspto-grants-1991_10
Patent number
US05061289

Reaction notes

Loading…