Methanol → Methyl 6-hydroxy-2-naphthoate

HRID 346081Notes

Reaction equation

HRID 346081 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([OH:14])=[O:13])[CH:6]=[CH:5]2.S(=O)(=O)(O)O.[CH3:20]O>>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([O:14][CH3:20])=[O:13])[CH:6]=[CH:5]2

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 855576-Hydroxy-2-naphthoic acid

Product 1

HCID 390995Methyl 6-hydroxy-2-naphthoate

Procedure

6-Hydroxy-2-naphthoic acid (60 g), methanol (240 ml) and sulphuric acid (12 ml) were refluxed together for 5 hours. The ester was isolated by pouring into water and recrystallised from methanol (50.0 g, 77.5% theory)

Sources & evidence

ORD record
ord-969569a0f4d24e4fab9018c4b8bba49b
Source dataset
uspto-grants-1991_10
Patent number
US05061399

Reaction notes

Loading…