HCID 19990383, compound → HCID 5276631, compound

HRID 346100Notes

Reaction equation

HRID 346100 reaction equation
Cl.[NH2:2][C:3]12[CH2:12][CH:7]3[CH2:8][CH:9]([CH2:11][C:5]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)([CH2:6]3)[CH2:4]1)[CH2:10]2.[H][H]>C(O)(=O)C.[Pt]=O>[NH2:2][C:3]12[CH2:12][CH:7]3[CH2:8][CH:9]([CH2:11][C:5]([CH:13]4[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]4)([CH2:6]3)[CH2:4]1)[CH2:10]2

Participants

5

Reactant 2

HCID 19990383HCID 19990383, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 5276631HCID 5276631, compoundYield 70%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

Dissolve 0.011 mol of 1-amino-3-phenyl adamantane (V) in 150 ml glacial acetic acid, mix with 0.3 g of platinum oxide (1% on activated carbon) and hydrate in a Parr apparatus at 35° C. at a hydrogen pressure of 3 bar. Subsequently, remove the catalyst by filtration and evaporate the filtrate to dryness. Take up the residue in methanol and precipitate the product with ether. Suck off and dry. (Yield: 70%).

Workup

  1. customSubsequently, remove the catalyst
  2. filtrationby filtration
  3. customevaporate the filtrate to dryness
  4. customprecipitate the product with ether
  5. customdry

Sources & evidence

ORD record
ord-86c99f59805d417a9e39f4b8f395daf9
Source dataset
uspto-grants-1991_10
Patent number
US05061703

Reaction notes

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