HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dimethyl-5-ethoxycarbonylbarbituric acid → 1,3-dimethyl-5-[4-(1-methyl-3-trifluoromethyl-1H-1,2,4-triazol-5-yloxy)phenylcarbamoyl]barbituric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dimethyl-5-ethoxycarbonylbarbituric acid | HCID 593714 | — |
| Reactant | 1-methyl-3-trifluoromethyl-5-(4-aminophenoxy)-1H-1,2,4-triazole | HCID 21298114 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1,3-dimethyl-5-[4-(1-methyl-3-trifluoromethyl-1H-1,2,4-triazol-5-yloxy)phenylcarbamoyl]barbituric acid | HCID 21298107 | — |
Reaction Steps
22.8 g of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 25.8 g of 1-methyl-3-trifluoromethyl-5-(4-aminophenoxy)-1H-1,2,4-triazole are heated under reflux in 200 ml of toluene for 4 hours. The crude product, which precipitates on cooling to room temperature, is isolated by filtration, washed with diethyl ether and dried. Yield: 39.2 g (89% of theory). Melting point: 202°-204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04762830 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-ae78a0b7dce342c2898166ac2686c055 |
| Source note | uspto-grants-1988_08 |