Acetic Acid → HCID 15077541, compound

HRID 346120Notes

Reaction equation

HRID 346120 reaction equation
[C:1]1([C:7]2[O:8]C3C(N=2)=NC=CC=3)C=CC=[CH:3][CH:2]=1.[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23]1[O:24][C:25]2[C:26]([N:32]=1)=[N:27][C:28]([CH3:31])=[CH:29][CH:30]=2.S(=O)(=O)(O)O.C(O)(=O)C>O>[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23]1[O:24][C:25]2[C:26]([N:32]=1)=[N:27][C:28]([CH3:31])=[CH:29][C:30]=2[C:7](=[O:8])[CH2:1][CH2:2][CH3:3]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 9990264HCID 9990264, compoundHCID 15711296HCID 15711296, compound

Product 1

HCID 15077541HCID 15077541, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Using the procedure described in Example 1, but replacing -phenyloxazolo[4,5-b]pyridine by 2-(2-fluorophenyl)-5-methyloxazolo[4,5-b]pyridine and using 1.5 ml of sulfuric acid, 5 ml of acetic acid (and not 7.5 ml) and 5 ml of water (and not 7.5 ml), and on purification by chromatography on silica gel (40 to 63μ; 70-230 mesh; eluent: ethyl acetate/toluene, 2:8), the product of the title is obtained.

Workup

  1. customon purification by chromatography on silica gel (40 to 63μ; 70-230 mesh; eluent: ethyl acetate/toluene, 2:8)
  2. customthe product of the title is obtained

Sources & evidence

ORD record
ord-8b39649090ce4412a401ffb280bb7901
Source dataset
uspto-grants-1991_10
Patent number
US05061713

Reaction notes

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