2-Fluorobenzoyl chloride → HCID 3413424, compound

HRID 346122Notes

Reaction equation

HRID 346122 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[NH2:11][C:12]1[C:13]([Cl:18])=[N:14][CH:15]=[CH:16][CH:17]=1>N1C=CC=CC=1>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:11][C:12]1[C:13]([Cl:18])=[N:14][CH:15]=[CH:16][CH:17]=1)=[O:5]

Participants

4

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 805282-Chloro-3-pyridylamine

Product 1

HCID 3413424HCID 3413424, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Procedure

4.44 g (28 mmol) of 2-fluorobenzoyl chloride are added to 30 ml of anhydrous pyridine at 0° C. while the temperature is maintained below 5° C. 3 g of 3-amino-2-chloropyridine in 20 ml of pyridine are added with stirring using a pressure equalizing funnel. After being left overnight at room temperature, the reaction medium is poured into an ice/water mixture. The solid obtained is filtered off and washed several times with water.

Workup

  1. temperatureis maintained below 5° C
  2. customThe solid obtained
  3. filtrationis filtered off
  4. washwashed several times with water

Sources & evidence

ORD record
ord-cf82a960cfec40c78b989e6f0253abdc
Source dataset
uspto-grants-1991_10
Patent number
US05061713

Reaction notes

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