Sulfuric Acid → HCID 15077544, compound

HRID 346123Notes

Reaction equation

HRID 346123 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[C:4]([NH:6][C:7]1[C:8]([Cl:13])=[N:9][CH:10]=[CH:11][CH:12]=1)=[O:5].S(=O)(=O)(O)O>O.C(O)(=O)C>[Cl:13][C:8]1[C:7]([NH:6][C:4](=[O:5])[C:3]2[CH:14]=[CH:15][CH:16]=[CH:17][C:2]=2[F:1])=[C:12]([C:4](=[O:5])[CH2:3][CH2:2][CH3:17])[CH:11]=[CH:10][N:9]=1

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 3413424HCID 3413424, compound

Product 1

HCID 15077544HCID 15077544, compoundYield 25%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

Using the procedure described in Examples 1 and 2, but replacing 2-phenyloxazolo[4,5-b]pyridine by 3-(2-fluorobenzoylamino)-2-chloropyridine and using 1.5 ml of concentrated sulfuric acid in 7.5 ml of water and 25 ml of acetic acid, and after the separation of 2-chloro-3-(2-fluorobenzoylamino)-6-butyrylpyridine, the expected product is obtained.

Workup

  1. customafter the separation of 2-chloro-3-(2-fluorobenzoylamino)-6-butyrylpyridine

Sources & evidence

ORD record
ord-b043c1001a40496cb06b1f6c468dbf13
Source dataset
uspto-grants-1991_10
Patent number
US05061713

Reaction notes

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