反应详情

To 75 ml ice-cooled 100% nitric acid was added gradually 7.25 g (25.3 mmol) 2-cyano-5-ethoxalylaminobenzotrifluoride. Stirring was continued at 25° C. for 3 h. The reaction mixture was poured into 500 ml ice-water to give a crude product. Recrystallization (ethanol-water) gave 5.1 g (61%) 2-cyano-5-ethoxalylamino-4-nitrobenzotrifluoride. M.p. 101°-102° C.

1. customto give a crude product
2. customRecrystallization (ethanol-water)