Ammonia → HCID 22419806, compound

Participants

Reaction Steps

To a solution of 1.0 g (3.36 mmol) 6-chloro-3-ethoxalylamino-2-nitrobenzonitrile in 75 ml tetrahydrofuran was added 25 ml dimethylformamide and 1.0 ml 25% aqueous ammonia. The mixture was hydrogenated at atm. pressure by using 100 mg 5% Pd-C as a catalyst. The precipitated product was filtered off and washed with tetrahydrofuran. The filter cake was washed several times with 5% aqueous potassium hydroxide. Acidification of the filtrate with 4N hydrochloric acid gave 0.57 g (72%) of 7-chloro-8-cyano-1-hydroxyquinoxaline-2,3(1H,4H)-dione. M.p. 280° C. decomp H-NMR (DMSO-d6) 12.3 (2H, broad s), 7.5 (2H, s). MS (m/e): 237 (M+, 10%).

Provenance & Evidence