Hydrochloric Acid → Ethyl 2-[(3,4-dicyanophenyl)amino]-2-oxoacetate

Participants

Reaction Steps

To a suspension of 7.0 g (25.1 mmol) 4-ethoxalylaminophthalamide in 75 ml dry pyridine was gradually added 4.1 ml (44.8 mmol) phosphorus oxychloride. Stirring was continued at 25° C. for 30 min. The reaction mixture was poured into 300 ml ice-cooled 4N hydrochloric acid to give 4.7 g (77%) of 4-ethoxalylaminopthalonitrile. M.p. 193.7° C.

Provenance & Evidence