Ammonia → HCID 19990430, compound

Participants

Reaction Steps

0.20 g (0.5 mmol) N-ethoxalyl-3,5-bistrifluoromethyl-2-nitroaniline in 10 ml tetrahydrofuran:dimethylformamide:25% aqueous ammonia (30:10:0.7) was hydrogenated at atm. pressure by using 5% Pd-C (0.02 g) as a catalyst. The reaction mixture was filtered and evaporated in vacuo. The residue was stirred with water, and the precipitate was filtered off to give 0.11 g (84%) of 6,8-bistrifluoromethyl-1-hydroxyquinoxaline- 2,3(1H,4H)-dione. M.p. decomp. 1H-NMR (DMSO-d6): 8.1 (s). MS (m/e): 314 (M+, 40%), 173 (45%), 69 (100%).

Provenance & Evidence