Hydrochloric Acid → HCID 19990472, compound

Participants

Reaction Steps

A solution of 2.0 g (5.9 mmol) N-ethoxalyl-4-chloro-6-nitro-3-trifluoromethylaniline in 50 ml dimethylformamide was hydrogenated at atm. pressure by using 200 mg 5% Pt-C as a catalyst. The reaction mixture was stirred with 4N hydrochloric acid and the crude product was filtered off. The crude product was dissolved in 25 ml 1N potassium hydroxide and the solution was acidified with concentrated hydrochloric acid. The precipitate was filtered off to give 310 mg 19%) of 7-chloro-1-hydroxy-6-trifluoromethylquinoxaline-2,3(1H,4H)-dione. M.p. decomp. MS (m/e): 280, 1H-NMR (DMSO-d6): 12.2 (1H, broad s), 7.6 (2H, m).

Provenance & Evidence