Water → 1-allyloxy-7-cyano-6-trifluoromethylquinoxaline-2,3(1H,4H)-dione

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.4 g (1.5 mmol) 7-cyano-1-hydroxy-6-trifluoromethylquinoxaline-2,3(1H,4H)-dione in 40 ml ethanol was added 20 ml 0.5 M phosphate buffer pH 7.4. The mixture was added 0.8 ml (9.3 mmol) allyl bromide, and then stirred at 25° C. for 4 h. Addition of 80 ml water gave 0.33 g (72%) 1-allyloxy-7-cyano-6-trifluoromethylquinoxaline-2,3(1H,4H)-dione as a precipitate. M.p. 239° C. decomp. (methanol-water). NMR (DMSO-d6) 7.9 (1H, s), 7.6 (1H, s), 6.1 (1H, m), 5.4 (2H, m), 4.7 (2H, d).

Provenance & Evidence