Phosphate → HCID 19990443, compound

Participants

Reaction Steps

To a solution of 0.3 g (1.1- mmol) 7-cyano-1-hydroxy-6-trifluoromethylquinoxaline 2,3(1H,4H)-dione in 30 ml ethanol was added 15 ml 0.5M phosphate buffer pH 7.4. The mixture was added 1 ml (16 mmol) iodomethane, and then stirred overnight. The reaction mixture was evaporated, and the residue was stirred with water to give a precipitate. Recrystallization (dimethylformamide-water) gave 0.2 g (63%) of 7-cyano-1-methoxy-6-trifluoromethylquinoxaline-2,3(1H,4H)-dione. M.p. 250° C. decomp. 1H-NMR (DMSO-d6): 7.9 (1H, s), 7.6 (1H, s), 4.07 (3H, s).

Provenance & Evidence