Cyclohexyl bromide → HCID 19990417, compound

Participants

Reaction Steps

To a solution of 0.3 g (1.1 mmol) 7-cyano-1-hydroxy-6-trifluoromethylquinoxaline -2,3(1H,4H)-dione in 30 ml ethanol was added 0.7 ml triethylamine and 1.5 ml (12 mmol) cyclohexylbromide. The reaction mixture was refluxed for 7 days and then evaporated in vacuo. The residue was stirred with water to give a precipitate (0.25 g. Recrystallization (dimethylformamide-water) gave 0.17 g (44%) of 7-cyano-1-cyclohexyloxy-6-trifluoromethylquinoxaline-2,3(1H,4H)-dione). M.p. 259° C. decomp. 1H-NMR (DMSO-d6): 8.0 (1H, s), 7.6 (1H, s), 4.3 (1H, m), 1.4 (8H, m).

Provenance & Evidence