HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-nitrobenzonitrile → 5-Amino-2-chlorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-nitrobenzonitrile | HCID 85504 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Amino-2-chlorobenzonitrile | HCID 10997234 | 43.1% |
Reaction Steps
A solution of 10.0 g (54.8 mmol) 2-chloro-5-nitrobenzonitril in 500 ml ethanol was hydrogenated at 40 psi by using 0.5 g 5% Pd-C as a catalyst. The catalyst was filtered off and the filtrate was evaporated in vacuo. Recrystallization (ethanol-water) gave 3.6 g (43%) 5-amino-2-chlorobenzonitril. M.p. 129-130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05061706 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-1cbba4641d134b3d8e723ba4bf254661 |
| Source note | uspto-grants-1991_10 |