2-[(Acetylthio)methyl]-3-phenylpropionic Acid → HCID 14390696, compound

Participants

Reaction Steps

React S-phenethyl-L-cysteine ethyl ester hydrochloride (2.85 g) and 3-acetylthio-2-benzylpropionic acid, (2.38 g) in a manner similar to that described in Example 1, Step 1 to give an amber oil. Chromatograph this oil on Prep 500 (2 silica gel cartridges) and elute with CH2Cl2 (4 L) and then CH2Cl2 :ethyl acetate 100:2 to give Isomer A, a white solid (1.32 g), m.p. 63°-64°, [α]D26 =-51.2° (MeOH); overlap Isomer A and Isomer B (0.63 g); and Isomer B, white solid (1.14 g), m.p. 84°-86°, [α]D26 =+5.3° (MeOH).

Provenance & Evidence