反应详情

To a solution of terephthalaldehyde mono(diethyl acetal) (1.9 ml, 9.6 mmol) in methanol (35 ml) was added sodium borohydride (1.1 g, 28.8 mmol) while cooling. After 5 minutes at room temperature the reaction was quenched with water (50 ml) and the mixture was extracted with ethyl acetate (2×50 ml). The combined extracts were washed with water and brine, dried over sodium sulfate and concentrated in vacuo, leaving title product as a colorless oil (1.81 g, 90%).

1. temperaturewhile cooling
2. customAfter 5 minutes at room temperature the reaction was quenched with water (50 ml)
3. extractionthe mixture was extracted with ethyl acetate (2×50 ml)
4. washThe combined extracts were washed with water and brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo