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Sulfuric Acid → Methyl 2-(Dimethoxymethyl)pyridine-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Trimethyl orthoformate | HCID 9005 | — |
| 反応物 | Methyl 6-formylpyridine-3-carboxylate | HCID 586269 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 2-(Dimethoxymethyl)pyridine-5-carboxylate | HCID 14459972 | 75% |
反応手順
To a solution of methyl 2-formylpyridine-5-carboxylate (2.00 g, 12.1 mmol) in methanol (20 ml) and trimethyl orthoformate (5 ml) was added H2SO4 (conc., 1.5 ml). After refluxing overnight, the reaction was cooled and concentrated to a thick slurry and then poured into saturated NaHCO3 (50 ml). The latter was extracted with ether (3×30 ml) and the combined organic layers dried (MgSO4) and concentrated to afford title product (1.91 g, 75%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05061717 |
| 出典データセット | uspto-grants-1991_10 |
| ORD ID | ord-5c2b0597d11440a1a0dae16aa413565e |
| 出典メモ | uspto-grants-1991_10 |