Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene → 2,2-Dibutyl-4-hydroxy-1-indanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene | HCID 241 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Butyl iodide | HCID 10962 | — |
| 반응물 | 4-{[tert-Butyl(dimethyl)silyl]oxy}-2,3-dihydro-1H-inden-1-one | HCID 15829199 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 생성물 | 2,2-Dibutyl-4-hydroxy-1-indanone | HCID 10659016 | — |
반응 단계
A mixture of 4-(tert-butyldimethylsilyl)oxy-1-indanone (524 mg), 1-iodobutane (0.91 ml), and potassium tert-butoxide (896 mg) in dry benzene (15 ml) was refluxed for 2 hours under nitrogen. The reaction mixture was allowed to cool and poured into water. The separated oil was extracted with ethyl acetate. The organic layer was washed with brine, and concentrated in vacuo. The residue was subjected to column-chromatography on silica gel (elution by 10% n-hexane in dichloromethane and then dichloromethane) to yield 2,2-dibutyl-4-hydroxy-1-indanone (150 mg) as crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05061718 |
| 출처 데이터셋 | uspto-grants-1991_10 |
| ORD ID | ord-b34b65a860e247639f4feac56a380174 |
| 출처 메모 | uspto-grants-1991_10 |