反应详情

A mixture of 100 g (0.44 mole) of 2-bromohexanoic acid ethyl ester (Aldrich) and 39.0 g (0.51 mole) of thiourea (Baker) in 600 mL of ethanol was stirred and heated on a steam bath for 2 hr. The solvent was evaporated under reduced pressure to leave a solid residue. A 1.0 g sample of this solid was recrystallized from ethanol-water to yield 0.8 g title compound as a white solid, mp 179°-182° C. (lit, mp 183° C., J. Amer. Chem. Soc. 49, 2064 (1927)).

1. temperatureheated on a steam bath for 2 hr
2. customThe solvent was evaporated under reduced pressure
3. customto leave a solid residue
4. customA 1.0 g sample of this solid was recrystallized from ethanol-water