反应详情

A mixture of 100 g (0.47 mole) of α-bromophenylacetic acid (Aldrich) and 41.0 g (0.54 mole) of thiourea (Baker) in 600 mL of ethanol was stirred and heated on a steam bath for 4 hr. The solvent was evaporated under reduced pressure to give 142.0 g crude title compound as a white solid. An analytical sample of title compound, mp 249°-252° C., was prepared from 95% ethanol as white flakes.

1. temperatureheated on a steam bath for 4 hr
2. customThe solvent was evaporated under reduced pressure