Water → HCID 51190539, compound

Participants

Reaction Steps

A mixture of 66.9 g (0.354 mole) of potassium phthalimide (98%, Aldrich) and 90.0 g (0.348 mole) of 4-(3-chloropropoxy)-3-methyl benzoic acid methyl ester in 450 mL of dimethyl formamide was stirred and heated at reflux for 5 hr then let stir at ambient temperature overnight. The reaction mixture was treated with 3 L of water and the resulting solid was collected by filtration to give 108.5 g (84%) of crude title compound. An 8.0 g sample of this solid was recrystallized from 2-propanol to yield 6.4 g (80%) of title compound as a white solid, mp 127°-128° C.

Provenance & Evidence