HCID 19990665, compound → HCID 19990661, compound

HRID 346265Notes

Reaction equation

HRID 346265 reaction equation
[CH2:1]([O:3][C:4]([CH:6]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH:7]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:8][C:9]([O:11]CC1C=CC=CC=1)=[O:10])=[O:5])[CH3:2]>O1CCOCC1.[Pd]>[CH2:28]([O:27][C:25]([CH:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:7]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[CH2:8][C:9]([OH:11])=[O:10])=[O:26])[CH3:29]

Participants

4

Reactant 1

HCID 19990665HCID 19990665, compound

Product 1

HCID 19990661HCID 19990661, compoundYield 87.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

To a solution of benzyl 4,4-bis(ethoxycarbonyl)-3-phenylbutyrate (3.98 g) in dioxane (50 ml) was added 10% palladium on carbon (0.5 g). The mixture was hydrogenated at 4 kgf/cm2 for 1 hour. The reaction mixture was filtered and the filtrate was evaporated off to give 4,4-bis(ethoxycarbonyl)-3-phenylbutyric acid (2.7 g) as an oil.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated off

Sources & evidence

ORD record
ord-ef8f0aa1a3234e9e9987764ae0086cda
Source dataset
uspto-grants-1991_10
Patent number
US05061730

Reaction notes

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