Sodium Hydroxide → HCID 53690096, compound

HRID 346272Notes

Reaction equation

HRID 346272 reaction equation
[OH-].[Na+].[C:3]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:12]([CH3:17])([CH3:16])[CH2:11][CH2:10][C:9]2([CH3:19])[CH3:18])(=[O:5])[CH3:4]>CO>[CH3:16][C:12]1([CH3:17])[CH2:11][CH2:10][C:9]([CH3:19])([CH3:18])[C:8]2[CH:7]=[C:6]([C:3](=[O:5])[CH:4]=[CH:3][C:6]3[CH:7]=[CH:8][C:13]([CH3:12])=[CH:14][CH:15]=3)[CH:15]=[CH:14][C:13]1=2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 27475621-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one

Product 1

HCID 53690096HCID 53690096, compoundYield 191.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 g of 50% strength sodium hydroxide solution were added dropwise to a solution of 50 g (0.22 mole) of 6-acetyl-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene and 26.1 g (0.22 mole) of 4-tolylaldehyde in 250 ml of methanol. The mixture was stirred overnight, after which it was poured onto ice/water and left to stand for several hours. The precipitated crystals were filtered off under suction and dried to give 70 g of 1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3-(4-tolyl)-prop-2-en-1-one of melting point 153°-154° C.

Workup

  1. additionafter which it was poured onto ice/water
  2. waitleft
  3. waitto stand for several hours
  4. filtrationThe precipitated crystals were filtered off under suction
  5. customdried

Sources & evidence

ORD record
ord-fc630a560a694299b14c657393cc43f9
Source dataset
uspto-grants-1991_10
Patent number
US05061705

Reaction notes

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