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Benzaldehyde → 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-methylbenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Furfural | HCID 7362 | — |
| 反応物 | 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid | HCID 13500657 | — |
| 生成物 | 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-methylbenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid | HCID 14230012 | — |
反応手順
In the described fashion of Example 1 replacing benzaldehyde with 2-furaldehyde and using the acid (1) (R=o,p-difluorophenyl) described in Example 7 one can obtain 1-o,p-difluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(2-furylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid (3) (R=o,p-difluorophenyl, Z=2-furan).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762845 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-1a191cc7e4e04639bdd01f241b0d1ede |
| 出典メモ | uspto-grants-1988_08 |