HCID 131717050, compound → HCID 137225471, compound

HRID 346389Notes

Reaction equation

HRID 346389 reaction equation
Cl[CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[C@H:26]([NH:27][C:28](=[O:71])[C:29](=[N:55][O:56][CH2:57][C:58]3[CH:63]=[CH:62][C:61]([O:64]COCCOC)=[CH:60][CH:59]=3)[C:30]3[N:31]=[C:32]([NH:35]C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[S:33][CH:34]=3)[C:25](=[O:72])[N:7]2[C:8]=1[C:9]([O:11]C(C1C=CC=CC=1)C1C=CC=CC=1)=[O:10].[SH:73][C:74]1[O:75][C:76]([C:79]2[CH:84]=[CH:83][C:82]([O:85]COCCOC)=[C:81]([O:92]COCCOC)[CH:80]=2)=[N:77][N:78]=1>>[NH2:35][C:32]1[S:33][CH:34]=[C:30]([C:29](=[N:55][O:56][CH2:57][C:58]2[CH:63]=[CH:62][C:61]([OH:64])=[CH:60][CH:59]=2)[C:28]([NH:27][C@@H:26]2[C:25](=[O:72])[N:7]3[C:8]([C:9]([OH:11])=[O:10])=[C:3]([CH2:2][S:73][C:74]4[O:75][C:76]([C:79]5[CH:84]=[CH:83][C:82]([OH:85])=[C:81]([OH:92])[CH:80]=5)=[N:77][N:78]=4)[CH2:4][S:5][C@H:6]23)=[O:71])[N:31]=1

Participants

3

Reactant 2

HCID 131717050HCID 131717050, compoundHCID 178496295HCID 178496295, compound

Product 1

HCID 137225471HCID 137225471, compoundYield 38%

Procedure

The same operation as in EXAMPLE 1 was conducted by using 2.04 g (2 mmol) of benzhydryl 3-chloromethyl-7β-{2-[4-(2-methoxyethoxymethoxy)benzyloxyimino]-2-(2-tritylaminothiazol-4-yl) acetamido}-3-cephem-4-carboxylate (syn-isomer) and 773 mg (2 mmol) of 2-mercapto-5-[3,4-di(2-methoxyethoxymethoxy) phenyl]-1,3,4-oxadiazole, whereby 530 g (yield: 38.0%) of the above identified compound was obtained.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-97e6b7ca61334eef901b521240501481
Source dataset
uspto-grants-1991_10
Patent number
US05061794

Reaction notes

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