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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 346418생성일: 2026년 10월 25일

Hydrazine hydrate (1:1) → 6-Amino-4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline

https://huagongshe.com/reaction/346418

반응식

참여 물질

역할이름HCID투입량
반응물Hydrazine hydrate (1:1)HCID 24654—
반응물4-[(3,4-Dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazolineHCID 21080001—
촉매NickelHCID 935—
생성물6-Amino-4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazolineHCID 2108000775%

반응 단계

4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline was reacted with hydrazine hydrate and Raney®Nickel, as described hereinabove, to produce 6-amino-4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline in 75% yield.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07172749B2
출처 데이터셋uspto-grants-2007_02
ORD IDord-52aec6f9f1334395bc181d147ce3e3db
출처 메모uspto-grants-2007_02