HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-methylbenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | 4-Pyridinecarboxaldehyde | HCID 13389 | — |
| Reactant | 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid | HCID 13500657 | — |
| Product | 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-methylbenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid | HCID 14230012 | — |
Reaction Steps
In the described fashion of Example 1 replacing benzaldehyde with 4-pyridinecarboxaldehyde and using the acid (1) (R=cyclopropyl) described in example 19 one obtains 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-pyridylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid (3); (R=cyclopropyl, Z=4-pyridine). mp 233°-234° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04762845 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-fc41b4fee65c441ea00ca8ac2d248510 |
| Source note | uspto-grants-1988_08 |