HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 11150792, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(Bromomethyl)-3-chlorobenzene | HCID 69838 | — |
| Reactant | 7-hydroxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one | HCID 12251017 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 11150792 | HCID 11150792 | — |
Reaction Steps
In an analogous manner to that described in Example 17 c), the alkylation of 7-hydroxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one [Example 19 b)] by 3-chlorobenzylbromide in the presence of potassium carbonate in 2-butanone yielded the 7-(3-chloro-benzyloxy)-1,3,4,5-tetrahydro-benzo[d]azepin-2-one as a white solid; MS: m/e=302 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07173023B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-9ebbf2a46ae544a8943adefd0473b640 |
| Source note | uspto-grants-2007_02 |