Trifluoroacetic acid → N-(4-Fluoro-2-(methylcarbamoyl)benzyl)-3-hydroxy-8,8-dimethyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-2-carboxamide

Participants

Reaction Steps

Intermediate 7, N-(4-fluoro-2-(methylcarbamoyl)benzyl)-3-(benzyloxy)-8,8-dimethyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-2-carboxamide was treated with trifluoroacetic acid, according to Method D to provide the title compound 1H NMR (300 MHz, CDCl3) δ ppm: 12.12 (1H, br), 8.71 (1H, br), 7.47 (1H, dd, J=8.1, 5.5 Hz), 7.05–7.2 (2H, m), 6.26 (1H, br), 4.59 (2H, d, J=6.6 Hz), 3.95–4.06 (2H, m), 3.00 (3H, d, J=4.8 Hz), 1.99–2.08 (2H, m), 1.31 (6H, s); HRMS (ESI) calcd for C19H22FN4O4(M+H) 389.1625, found 389.1625.

Provenance & Evidence