Trifluoroacetic acid → HCID 54677955, compound

Participants

Reaction Steps

Intermediate 12, N-(4-fluoro-2-(methylcarbamoyl)benzyl)-3-(benzyloxy)-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxamide was treated with trifluoroacetic acid, according to Method D to provide the title compound. 1H NMR (300 MHz, CDCl3) δ ppm: 11.76 (1 H, br), 8.84 (1 H, t, J=5.9 Hz), 7.46 (1 H, dd, J=8.4, 5.5 Hz), 7.04–7.18 (2 H, m), 6.22 (1 H, s), 4.57 (2 H, d, J=6.6 Hz), 3.93 (2 H, t, J=6.4 Hz), 3.00 (3 H, d, J=4.8 Hz), 1.88–2.00 (2 H, m), 1.67–1.74 (2 H, m), 1.33–1.39 (6 H, m); HRMS (ESI) calcd for C20H24FN4O4 (M+H) 403.1782, found 403.1783.

Provenance & Evidence