Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | HCID 86595860 | HCID 86595860 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86595859 | HCID 86595859 | — |
Reaction Steps
DMF was added to tert-butyl [3-(1-bromoethyl)-1,2,4-thiadiazol-5-yl]carbamate (1.9 mmol), NaCN (1.1 eq) and NaI (1 eq). The reaction mixture was stirred for 30 min at 140° C. The reaction mixture was cooled to room temperature and the solvent was removed under reduced pressure. Standard work-up and recrystallization from EtOH afforded tert-butyl [3-(1-cyanoethyl)-1,2,4-thiadiazol-5-yl]carbamate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07173030B2 |
|---|
| Source dataset | uspto-grants-2007_02 |
|---|
| ORD ID | ord-fcdf4224fb2f4dbc9790699d98331949 |
|---|
| Source note | uspto-grants-2007_02 |
|---|
