HCID 86595859, compound → HCID 86611452, compound

Participants

Reaction Steps

tert-Butyl [3-(1-cyanoethyl)-1,2,4-thiadiazol-5-yl]carbamate (0.65 mmol) was dissolved in MeOH (15 mL) and a catalytic amount of Raney-Ni (50% in H2O) was added. The reaction mixture was stirred at room temperature for 3 h under H2 (50 psi). The reaction mixture was filtered through a pad of CELITE and the solvent was removed under reduced pressure. Purification using preparative LCMS afforded the tert-butyl [3-(2-amino-1-methylethyl)-1,2,4-thiadiazol-5-yl]carbamate.

Provenance & Evidence