tert-Butyl isocyanate → 1-[2-Amino-6-(2,3-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

HRID 3465Notes

Reaction equation

HRID 3465 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[C:19]([NH2:20])=[N:18][C:12]2[N:13]=[C:14]([NH2:17])[N:15]=[CH:16][C:11]=2[CH:10]=1.[C:21]([N:25]=[C:26]=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[NH2:17][C:14]1[N:15]=[CH:16][C:11]2[CH:10]=[C:9]([C:3]3[CH:4]=[CH:5][CH:6]=[C:7]([CH3:8])[C:2]=3[CH3:1])[C:19]([NH:20][C:26]([NH:25][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:27])=[N:18][C:12]=2[N:13]=1

Participants

3

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 218500186-(2,3-Dimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Product 1

HCID 53291201-[2-Amino-6-(2,3-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

Procedure

The title compound was prepared from 0.5007 g of 6-(2,3-dimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 92 and 0.23 mL tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with a gradient of CHCl3 :EtOAc (2:1) to CHCl3 :EtOAc (1:1); mp 326°-330° C., MS(CI).

Workup

  1. customThe product was purified by MPLC
  2. washeluting with a gradient of CHCl3 :EtOAc (2:1) to CHCl3 :EtOAc (1:1)

Sources & evidence

ORD record
ord-05b4c1e1bd144a7cb6cd10e428c21328
Source dataset
uspto-grants-1998_03
Patent number
US05733913

Reaction notes

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