Acetic Anhydride → HCID 23115893, compound

HRID 346502Notes

Reaction equation

HRID 346502 reaction equation
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([C:16]4[CH:17]=[C:18]([CH:20]=[CH:21][CH:22]=4)[NH2:19])=[N:14][N:15]=3)[N:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([C:16]4[CH:17]=[C:18]([CH:20]=[CH:21][CH:22]=4)[NH:19][C:23](=[O:25])[CH3:24])=[N:14][N:15]=3)[N:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 23115885HCID 23115885, compound

Product 1

HCID 23115893HCID 23115893, compound

Procedure

A mixture of 3-[6-(piperidin-1-yl)-1,2,4-triazolo[4,3-b]pyridazine-3-yl]aniline (180 mg) and acetic anhydride (3 ml) was stirred at room temperature for 6 hours. The reaction solution was concentrated under reduced pressure, and the resultant crude crystals were washed with diethyl ether to obtain 3′-[6-(piperidin-1-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]acetoanilide (190 mg) as colorless crystals.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. washthe resultant crude crystals were washed with diethyl ether

Sources & evidence

ORD record
ord-afaeb20363c941828e8382f657195956
Source dataset
uspto-grants-2007_02
Patent number
US07173033B2

Reaction notes

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