HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 346534Generated: October 30, 2026
Ethyl chloroformate → Ethyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinylcarbamate
https://huagongshe.com/reaction/346534
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine trihydrochloride | HCID 21934818 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Ethyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinylcarbamate | HCID 17973412 | — |
Reaction Steps
107.35 mg (0.31 mmol) of 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4,5,6-pyrimidinetriamine trihydrochloride from Example 8A are added to 5 ml of pyridine, and the mixture is cooled to 0° C. 33.25 mg (0.31 mmol) of ethyl chloroformate are added, and the reaction is left to stir at RT overnight. The pyridine is evaporated in vacuo in a rotary evaporator, and the residue is purified by preparative RP-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07173037B2 |
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| Source dataset | uspto-grants-2007_02 |
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| ORD ID | ord-6aa787223efe4e0c953eee3435ce2459 |
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| Source note | uspto-grants-2007_02 |
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