2,2-Dimethylpropyl carbonochloridate → Neopentyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinylcarbamate

Participants

Role	Name	HCID	Charge
Reactant	2,2-Dimethylpropyl carbonochloridate	HCID 3352185	—
Reactant	2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine trihydrochloride	HCID 21934818	—
Solvent	Pyridine	HCID 1049	—
Product	Neopentyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinylcarbamate	HCID 17973416	—

Reaction Steps

Prepared in analogy to Example 2 with 100 mg (0.29 mmol) of 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4,5,6-pyrimidinetriamine trihydrochloride from Example 8A, 5 ml of pyridine and 43 mg (0.29 mmol) of neopentyl chlorocarbonate.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07173037B2
Source dataset	uspto-grants-2007_02
ORD ID	ord-89de3eb873cc4b9e8f5979e8c196f060
Source note	uspto-grants-2007_02