反应详情

A solution of 7-(1-(tert-butoxycarbonyl)piperidin-4-ylmethoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (2.32 g, 4.6 mmol) in methylene chloride (23 ml) containing TFA (5 ml) was stirred at ambient temperature for 1 hour. The volatiles were removed under vacuum. The residue was partitioned between ethyl acetate and sodium hydrogen carbonate. The organic solvent was removed under vacuum and the residue was filtered. The precipitate was washed with water, and dried under vacuum. The solid was azeotroped with toluene and dried under vacuum to give 6-methoxy-7-(piperidin-4-ylmethoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (1.7 g, 92%).

1. customThe volatiles were removed under vacuum
2. customThe residue was partitioned between ethyl acetate and sodium hydrogen carbonate
3. customThe organic solvent was removed under vacuum
4. filtrationthe residue was filtered
5. washThe precipitate was washed with water
6. customdried under vacuum
7. customThe solid was azeotroped with toluene
8. customdried under vacuum