HRID346576

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID797562

1-(thien-2-ylcarbonyl)piperazine

C9H12N2OS

HCID2785748

3-Quinolinecarbonitrile, 4-chloro-1,2-dihydro-1-methyl-2-oxo-

C11H7ClN2O

PRODUCTS

生成物

结构：Cn1c(=O)c(C#N)c(N2CCN(C(=O)c3cccs3)CC2)c2ccccc21

HCID21081924

未命名化合物

收率 98%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

CONDITIONS

反应条件

温度: 120 °C

PROCEDURE

实验过程

Piperazine-1-yl-thiophen-2-yl-methanone (600 mg, 3.06 mmol) was added to a solution of Compound 3 (319 mg, 1.46 mmol) in toluene (40 mL) and heated overnight at 120° C. The solvent was removed under vacuum. The residue was suspended in water, sonicated, and filtered to yield 540 mg (98%) of white solids. M.P. 247° C. 1H NMR (DMSO-d6): δ 3.58 (s, 3H), 3.63 (m, 4H), 3.92 (m, 4H), 7.16 (t, J=4.8 Hz, 1H), 7.33 (t, J=7.5 Hz, 1H), 7.48 (d, J=3.5 Hz, 1H), 7.59 (d, J=8.5 Hz, 1H), 7.75 (t, J=7.25, 2H), 7.79 (d, J=4.8 Hz, 1H) 7.92 (d, J=7.5 Hz, 1H). EIMS m/z 379 (M+1), 401 (M+23). Anal. (C20H18N4O2S) C, H, N.

WORKUP

后处理

customThe solvent was removed under vacuum
customsonicated
filtrationfiltered