(3,5-Dimethylphenyl)acetonitrile → 6-(3,5-Dimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

HRID 3466Notes

Reaction equation

HRID 3466 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]#[N:11])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[NH2:12][C:13]1[N:18]=[C:17]([NH2:19])[C:16]([CH:20]=O)=[CH:15][N:14]=1>>[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]([NH2:11])=[N:19][C:17]3[N:18]=[C:13]([NH2:12])[N:14]=[CH:15][C:16]=3[CH:20]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 123481(3,5-Dimethylphenyl)acetonitrileHCID 3091762,4-Diaminopyrimidine-5-carbaldehyde

Product 1

HCID 218500386-(3,5-Dimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Procedure

The title compound was prepared according to Example 1, starting from 2.0 g of 3,5-dimethylphenyl-acetonitrile and 1.81 g of 2,4-diamino-5-pyrimidine-carboxaldehyde; mp 298°-302° C., MS(CI).

Sources & evidence

ORD record
ord-779916ef9f6645fd852eee00cd88177c
Source dataset
uspto-grants-1998_03
Patent number
US05733913

Reaction notes

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