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Acetic Acid → 6-Bromo-2-pyridin-2-ylquinoline-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 5-Bromoisatin | HCID 6889 | — |
| 反応物 | 2-Acetylpyridine | HCID 14286 | — |
| 溶媒 | Potassium Hydroxide | HCID 14797 | — |
| 生成物 | 6-Bromo-2-pyridin-2-ylquinoline-4-carboxylic acid | HCID 759123 | — |
反応手順
To a suspension of 5-bromo isatin (5 g, 20.5 mmol) and 2-acetylpyridine (2.5 g, 20.5 mmol) in aqueous KOH (1.2 g, 33%) was added EtOH until a solution formed. The mixture was refluxed over night. The reaction mixture was neutralized with HOAc (50%) and filtered. The solid was resuspended in EtOH and filtered to give the title compound (5.5 g). LC: 1.66 and MH+: 329.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07173042B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-66ea86aa294340e2ad098a4c0c526363 |
| 出典メモ | uspto-grants-2007_02 |