Diethyl Ether → HCID 21080267, compound

Participants

Reaction Steps

N-(4-Pyridyl)piperazine (0.163 g) was added, in one portion, to a stirred solution of 5-(6-bromonaphth-2-ylsulphonyl)phthalic anhydride (0.417 g.) in DMF (10 ml.) and the mixture was stirred at ambient temperature for 1 hour. Diethyl ether (40 ml.) was added and the mixture was stirred rapidly. The resultant white, amorphous precipitate was recovered by filtration. There was thus obtained a 1:1 mixture (0.474 g., 81%) of: 5-(6-bromonaphth-2-ylsulphonyl)-2-[4-(4-pyridyl)piperazin-1-ylcarbonyl]benzoic acid and 4-(6-bromonaphth-2-ylsulphonyl)-2-[4-(4-pyridyl)piperazin-1-ylcarbonyl]benzoic acid; the mixture giving the following characterising data;

Provenance & Evidence