Sodium Hydroxide → HCID 18357091, compound

HRID 346672Notes

Reaction equation

HRID 346672 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:23]=[CH:22][C:17]([C:18]([O:20]C)=[O:19])=[CH:16][CH:15]=3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[N:1]1[CH:2]=[CH:3][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:23]=[CH:22][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=3)[CH2:9][CH2:8]2)=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18357078HCID 18357078, compound

Product 1

HCID 18357091HCID 18357091, compoundYield 52.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the product of step (a) (849 mg) in methanol (15 ml) was added 2N sodium hydroxide (6.8 ml) and the resulting mixture was stirred for 3 hours. The mixture was evaporated to dryness. The resulting gum was dissolved in water (7 ml) and acidified with acetic acid. The mixture was filtered to give 4-(4-(4-pyridyl)piperazin-1-ylmethyl)benzoic acid (429 mg);

Workup

  1. customThe mixture was evaporated to dryness
  2. dissolutionThe resulting gum was dissolved in water (7 ml)
  3. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-d6aedeaae8fd49af82fc418cf2d3bfc5
Source dataset
uspto-grants-2007_02
Patent number
US07173025B1

Reaction notes

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