Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → 2-[1-(4-Pyridyl)piperidin-4-ylmethoxy]aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| 반응물 | N-Boc-2-aminophenol | HCID 4935485 | — |
| 반응물 | (1-(Pyridin-4-YL)piperidin-4-YL)methanol | HCID 11310048 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-[1-(4-Pyridyl)piperidin-4-ylmethoxy]aniline | HCID 21080292 | 236.4% |
반응 단계
To a solution of 1-(4-pyridyl)piperidin-4-ylmethanol (357 mg) and 2-tert-butyloxycarbonylaminophenol (328 mg) in tetrahydrofuran (15 ml) was added triphenylphosphine (447 mg) followed by diethyl azodicarboxylate (0.27 ml). The mixture was stirred at room temperature for 18 hours. The reaction mixture was concentrated to a gum which was purified by column chromatography on silica eluting with methanol/dichloromethane (10:90) to give the tert-butyloxycarbonyl protected derivative of 2-[1-(4-pyridyl)piperidin-4-ylmethoxy]aniline (1.05 g);
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07173025B1 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-d422d900877642118b1fc47c2f655ce1 |
| 출처 메모 | uspto-grants-2007_02 |