Triethylamine → HCID 17915734, compound

Participants

Reaction Steps

5-(6-Bromonaphth-2-ylsulphonyl)-2-methoxycarbonylbenzoic acid(97 mg) was dissolved in dichloromethane (1 ml.). Oxalyl chloride (126 mg) was added and the mixture stirred at ambient temperature for 1 hour. The mixture was evaporated to give a solid which was redissolved in dichloromethane (1 ml) and added to a solution of N-(4-pyridyl)piperazine (34 mg) and triethylamine (108 mg) in dichloromethane (2 ml). After stirring for 2 hours at ambient temperature the mixture was diluted with ethyl acetate (100 ml), washed with water (2×25 ml), dried (MgSO4) and evaporated to give an oil, which was further purified by chromatography (Mega Bond Elut column, eluted with dichloromethane containing an increasing proportion of methanol, 0-5%) to give 1-[5-(6-bromonaphth-2-ylsulphonyl)-2-methoxycarbonylbenzoyl]-4-(4-pyridyl)piperazine (55 mg);

Provenance & Evidence