tert-Butyl isocyanate → 1-[2-Amino-6-(3,5-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

Participants

Reaction Steps

The title compound was prepared from 0.3 g of 6-(3,5-dimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 94 and 0.14 mL of tert-butyl isocyanate according to Example 2. The product is purified by MPLC eluting with 1:1 CHCl3 :EtOAc; mp 180°-182° C., CIMS (1% ammonia in methane): m/z (relative intensity) 365 (MH+ +1, 16), 366 (MH+ +2, 3), 84 (100).

Provenance & Evidence