反应详情

温度

60 °C

Ethyl 1,4-diethoxy-2,3-naphthalenedicarboxylate (32 g, 89 mmol) was added to a solution of sodium hydroxide (20 g) in ethanol (200 ml) and water (40 ml) and stirred for 1.5 h at 60° C. The reaction was cooled and the thick white suspension was filtered. The solid was dissolved in a mixture of ethyl acetate (200 ml) and water (800 ml). The layers were separated and the aqueous was acidified with hydrochloric acid (2M, 120 ml). The aqueous was extracted with ethyl acetate (2×) and the combined organics were dried (MgSO4). Evaporation of the solvent under vacuum gave the title compound as a white solid (25 g, 92%).

1. temperatureThe reaction was cooled
2. filtrationthe thick white suspension was filtered
3. dissolutionThe solid was dissolved in a mixture of ethyl acetate (200 ml) and water (800 ml)
4. customThe layers were separated
5. extractionThe aqueous was extracted with ethyl acetate (2×)
6. dry with materialthe combined organics were dried (MgSO4)
7. customEvaporation of the solvent under vacuum