反应详情

N-[5-(4-Methyl-1-piperazinyl)-2-nitrophenyl]benzenesulfonamide (0.600 g, 1.59 mmol) was dissolved in THF (20 mL) followed by the addition of Raney-Ni (0.322 g, in ethanol) and hydrazine hydrate (0.100 g, 2.0 mmol). The reaction mixture was stirred for 1 h, filtered through Celite and concentrated. The residue was dissolved in pyridine (12 mL) and divided in 12 equal parts. To one part was added 2-methoxy-4-methyl-benzenesulfonylchloride (44 mg, 0.20 mmol). The reaction mixture was stirred overnight, poured into petroleum ether to form a precipitate that was collected by centrifugation. The precipitate was purified by purified by column chromatography (SiO2, CH2Cl2/MeOH 95:5 to 9:1). The pure product was dissolved in MeOH and treated with HCl/diethyl ether to give 21 mg, (28% yield). MS (posES-FIA) m/z=found: 530.1635; Calcd: 530.1658.

1. filtrationfiltered through Celite
2. concentrationconcentrated
3. dissolutionThe residue was dissolved in pyridine (12 mL)
4. stirringThe reaction mixture was stirred overnight
5. customto form a precipitate that
6. customwas collected by centrifugation
7. customThe precipitate was purified
8. customby purified by column chromatography (SiO2, CH2Cl2/MeOH 95:5 to 9:1)
9. dissolutionThe pure product was dissolved in MeOH
10. additiontreated with HCl/diethyl ether
11. customto give 21 mg, (28% yield)